Providing the history and significance of the varied collection of articles in this American Indian Culture and Research Journal special issue, coeditors David Shorter and Kim TallBear describe involvement in an Indigenous studies working group formed in conjunction with the Making Contact 2018 workshop hosted by the Berkeley SETI (Search for Extraterrestrial Intelligence) Research Center. As a whole, “Settler Science, Alien Contact, and Searches for Intelligence” takes a critical eye to frontiers, space exploration, the history of science, and the colonial politics of surveillance technologies.